GBD 2021 stroke burden across 204 countries: age-standardised incidence -21.8%, deaths -39.4%, DALYs -38.7% (1990-2021), but absolute counts up; 84.1% of stroke DALYs attributable to 23 risk factors (metabolic 68.8%, environmental 36.7%, behavioural 35.2%).
Preclinical study in male Wistar rats showing that the 35 kDa claudin-5 (CLDN5) isoform 1, produced by a novel intra-exonic splice junction conserved in human hypoxic endothelial cells, correlates with edema, neurological deficit, and hemorrhage at 24 h after thromboembolic stroke.
A longitudinal Oxford cohort found that cognitive recovery after stroke is common but heterogeneous: acute cognitive burden was the strongest predictor of chronic impairment, while a small subgroup declined over time.
In the HOPE randomized trial, reperfusion-guided systolic blood pressure targets after successful thrombectomy improved 90-day functional independence and reduced hemorrhagic transformation without increasing symptomatic intracranial hemorrhage or mortality.
In adults 3 to 18 months after stroke, adding action observation to virtual-reality training improved paretic-hand dexterity more than virtual reality alone, with the between-group advantage persisting at 6 months.
In 4,765 patients receiving oral antithrombotic therapy, severe MRI-defined cerebral small vessel disease was associated with functional decline over 24 months even after accounting for major bleeding and ischemic events.
In the MIND trial, minimally invasive surgery with the Artemis device within 72 hours did not significantly reduce 30-day mortality or improve 180-day disability in supratentorial ICH versus medical management alone.
Argatroban + antiplatelet in END (n=601): 90-d mRS 0–3 80.5% vs 73.3% (aRR 1.10, P=0.03); sICH 0.9% vs 0.7% (P=0.78); mRS shift OR 0.71 (P=0.02).
In a matched multicenter cohort of 746 large-vessel-occlusion patients undergoing bridging therapy, tenecteplase produced nearly twice the thrombus migration of alteplase (19.3% vs 11.3%), concentrated in the first 60 minutes after IVT, and migration independently predicted functional independence.
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